Video Credit- @helixanimation
A beautiful video of the macrophage immune response to the presence of E.coli in the digestive tract | Via @oogenebiotech
Macrophages have a massive spread throughout the body. Immature macrophages in the bloodstream are also called monocytes. Monocytes typically make up about 5% of the population of leukocytes. Adult macrophages in the histocytic connective tissue and those that cover the walls of the liver sinusoid are also known as Coplex cells. The macrophages in the microglia of the brain and finally those in the lungs are called alveolar macrophages. A large number of macrophages reside in the spleen, bone marrow and lymph nodes. Regardless of the name and location, all of these cells are macrophages and are part of the phagocytic system of monocots.
New studies show that macrophages are essential for heartbeat. This makes macrophages a good target for treating diseases like arrhythmias. Studies in mice lacking macrophage showed that in these animals, the electrical rhythm of the heart was abnormal.
The researchers found that macrophages in the atrioventricular node or AV node are abundant in mice and humans. This node also contains muscle cells that can transmit the contraction signal.
When they cultured the heart muscle cells and macrophages in the dish, they found that these two types of cells were physically related and simultaneously electrically stimulated. Due to these interactions, macrophages facilitated the initiation of adjacent muscle cells.